• Exp Ther Med · Jun 2015

    Association between EML4-ALK fusion gene and thymidylate synthase mRNA expression in non-small cell lung cancer tissues.

    • Chun-Wei Xu, Gang Wang, Wu-Long Wang, Wen-Bin Gao, Chuan-Jun Han, Jing-Shan Gao, Li-Ying Zhang, Yang Li, Lin Wang, Yu-Ping Zhang, Yu-Wang Tian, and Dong-Dong Qi.
    • Department of Pathology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China.
    • Exp Ther Med. 2015 Jun 1; 9 (6): 2151-2154.

    AbstractThis study aimed to investigate the association of the mRNA expression of the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene with that of thymidylate synthase (TYMS) in non-small cell lung cancer (NSCLC) tissues. Quantitative polymerase chain reaction was used to detect the expression of EML4-ALK fusion gene and TYMS mRNA in 257 cases of NSCLC. The positive rate of EML4-ALK fusion gene was 4.28% in the NSCLC tissues (11/257), and was higher in nonsmokers than in smokers (P<0.05); TYMS mRNA expression was detected in 63.42% (163/257) of cases. An association of the EML4-ALK fusion gene with TYMS expression was detected; a low expression level of TYMS mRNA was observed more frequently when the EML4-ALK fusion gene was present than when it was not detected (P<0.05). In conclusion, patients positive for the EML4-ALK fusion gene in NSCLC tissues are likely to have a low expression level of TYMS, and may benefit from the first-line chemotherapy drug pemetrexed.

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