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Cell. Mol. Biol. (Noisy-le-grand) · Nov 1998
Characterisation of a novel AGE-compound derived from lysine and 3-deoxyglucosone.
- I C Skovsted, M Christensen, J Breinholt, and S B Mortensen.
- Health Care Discovery, Novo Nordisk A/S, Bagsvaerd, Denmark.
- Cell. Mol. Biol. (Noisy-le-grand). 1998 Nov 1; 44 (7): 1159-63.
AbstractDicarbonyl compounds are supposed to be reactive intermediates in the non-enzymatic glycation of proteins. A process that eventually could lead to the development of late diabetic complications. Glyoxal lysine dimer (GOLD) and methylglyoxal lysine dimer (MOLD) have previously been described as such reactive dicarbonyls. Here a new compound 3-deoxyglucosone lysine dimer (DOLD), a cross-link resulting from the reaction between hippuryl-lysine and 3-deoxyglucosone, has been isolated by HPLC and the structure determined by mass spectrometry and NMR.
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