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- Simone Kattner, Frank Herbstreit, Karsten Schmidt, Philip Stevens, Silke Grumaz, Simon Dubler, Peter-Michael Rath, and Thorsten Brenner.
- From the Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
- A A Pract. 2021 May 6; 15 (5): e01447.
AbstractAspergillus spp. are widespread environmental pathogens that can induce invasive aspergillosis, especially in immunocompromised patients. An 86-year-old female patient presented with a rare case of invasive cerebral aspergillosis. The aspergilloma invaded the intracranial region originating from the ethmoidal sinus and the orbital apex. In contrast to routine diagnostic procedures, next-generation sequencing (NGS) was able to identify the fungal pathogen in the cerebrospinal fluid as well as in plasma samples, supporting the biopsy-based diagnosis of invasive cerebral aspergillosis. Therefore, NGS-based diagnostics may be of particular importance for difficult-to-diagnose disease states, when conventional diagnostic procedures fail.Copyright © 2021 International Anesthesia Research Society.
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