• D Chan, S J Crutch, and E K Warrington.
• Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, UK. d.chan@dementia.ion.ucl.ac.uk
• J. Neurol. Neurosurg. Psychiatr. 2001 Oct 1; 71 (4): 515-7.

AbstractA 64 year old woman with posterior cortical atrophy secondary to probable Alzheimer's disease is described. Her presenting symptom was of seeing objects as abnormally coloured after prior exposure to a coloured stimulus. Formal testing disclosed that the patient experienced colour after-images of abnormal latency, duration, and amplitude.The demonstration of prolonged colour after-images in a patient with a cortical disease process provides strong evidence that the generation of colour after-images is mediated at least in part by the visual cortex. A mechanism for the generation of colour after-images is proposed in which abnormal prolongation of the images results from excessive rebound inhibition of previously excited wavelength selective neurons in V1. This may occur as a consequence of the relative sparing of inhibitory interneurons in V1 in the context of the degeneration of excitatory neurons that occurs in Alzheimer's disease.

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