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Review
Hot Topics in Primary Care: Role of the Kidney and SGLT-2 Inhibition in Type 2 Diabetes Mellitus.
- Kevin Miller and Eden M Miller.
- Executive Director and Co-founder, Diabetes Nation, High Lakes Health Care, St. Charles Hospital, Bend, OR, USA.
- J Fam Pract. 2015 Dec 1; 64 (12 Suppl): S54-8.
AbstractSGLT-2 inhibitors provide a complementary mechanism of glucose lowering and can be used as monotherapy or in combination with other medications, including insulin. In addition to improved glycemic control, which generally is maintained over 2 years, SGLT-2 inhibitors provide reductions in body weight and systolic blood pressure. Increases in LDL-C and HDL-C also have been observed. A requirement for adequate renal function is a limitation in patients with CKD. A low incidence of hypoglycemia, ability to promote weight loss, and availability as an oral formulation diminish common barriers to glucose-lowering therapy.
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