• Scand. J. Infect. Dis. · Jan 1997

    Case Reports

    Interleukin-6 in the fever and multiorgan crisis of pheochromocytoma.

    • A Salahuddin, T Rohr-Kirchgraber, R Shekar, B West, and J Loewenstein.
    • Department of Medicine, Meridia Huron Hospital.
    • Scand. J. Infect. Dis. 1997 Jan 1; 29 (6): 640-2.

    AbstractA 31-y-old black man with neurofibromatosis, alcoholism and hypertension was admitted because of abdominal pain, hematemesis and cough. In the hospital he had prolonged fever and developed a multiorgan crisis. Despite thorough investigation, no infectious cause for fever was found. Urinary catecholamines and metabolites were markedly elevated. Computerized tomography revealed a mass abutting the left kidney. A diagnosis of pheochromocytoma was made, and as soon as treatment with phenoxybenzamine and propranolol was begun, the fever resolved. Serum interleukin-6 (IL-6) concentration was initially elevated, decreased after the start of adrenergic blockade, and gradually fell to an undetectable level after surgery. These observations suggest that interleukin-6 might have been causally related to the patient's fever and possibly the multiorgan crisis.

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