• Isabelle Mourand, Pauline Malissart, Cyril Dargazanli, Erika Nogue, Stephane Bouly, Nicolas Gaillard, Yassine Boukriche, Lucas Corti, Marie-Christine Picot, Olivier Beaufils, Mohamed Chbicheb, Denis Sablot, Alain Bonafe, Vincent Costalat, and Caroline Arquizan.
• Department of Neurology, CHRU, Gui de Chauliac Hospital, Montpellier, France. Electronic address: i-mourand@chu-montpellier.fr.
• J Stroke Cerebrovasc Dis. 2019 Feb 1; 28 (2): 259-266.

BackgroundMechanical thrombectomy (MT) in association with intravenous thrombolysis is recommended for treatment of acute ischemic stroke (AIS), with large vessel occlusion (LVO) in the anterior circulation. Because MT is only available in comprehensive stroke centers (CSC), the challenge of stroke organization is to ensure equitable access to the fastest endovascular suite. Our aim was to evaluate the feasibility, efficacy, and safety of MT in patients initially managed in 1 CSC (mothership), compared with patients first managed in primary stroke center (PSC), and then transferred to the CSC for MT (drip-and-ship).MethodsWe retrospectively analyzed 179 consecutive patients (93 in the mothership group and 86 in the drip-and-ship group), with AIS secondary to LVO in the anterior cerebral circulation and a clinical-radiological mismatch (NIHSS ≥ 8 and DWI-ASPECT score ≥5), up to 6 hours after symptoms onset. We evaluated 3-month functional modified Rankin scale (mRS), periprocedural time management, mortality, and symptomatic intracranial haemorrhage (sICH).ResultsDespite significant longer process time in the drip-and-ship group, mRS ≤ 2 at 3 months (39.8% versus 44.1%, P = .562), Thrombolysis in cerebral infarction 2b-3 (85% versus 78%, P = .256), and sICH (7.0% versus 9.7%, P = .515) were similar in both group regardless of baseline clinical or radiological characteristics. After multivariate logistic regression, the predictive factors for favorable outcome were age (odds ratio [OR] -5years= 1.32, P < .001), initial NIHSS (OR -5points = 1.59, P = .010), absence of diabetes (OR = 3.35, P = .075), and the delay magnetic resonance imagining-puncture (OR -30min = 1.16, P = .048).ConclusionsOur study showed encouraging results from a regional protocol of MT comparing patients transferred from PSC or brought directly in CSC.Copyright © 2018. Published by Elsevier Inc.

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