• Sara Suikkanen, Paula Soukkio, Kaisu Pitkälä, Sanna Kääriä, Hannu Kautiainen, Sarianna Sipilä, Katriina Kukkonen-Harjula, and Markku Hupli.
• Rehabilitation, South Karelia Social and Health Care District, Valto Käkelän katu 3, 53130, Lappeenranta, Finland. sara.suikkanen@eksote.fi.
• Aging Clin Exp Res. 2019 Oct 1; 31 (10): 1419-1427.

BackgroundIncreasing the level of physical activity among persons with signs of frailty improves physical functioning. There is a lack of long-term supervised physical exercise intervention studies including a validated definition of frailty.AimsTo present baseline characteristics of persons with signs of frailty participating in a randomized long-term home-based physical exercise trial (HIPFRA), and to study associations between the severity of frailty, functional independence and health-related quality-of-life (HRQoL).MethodsThree hundred persons, ≥ 65 years old and with signs of frailty (assessed by Fried´s phenotype criteria) were recruited from South Karelia, Finland and randomized to a 12-month physiotherapist-supervised home-based physical exercise program (n = 150), and usual care (n = 150). Assessments at the participants' homes at baseline, and after 3, 6 and 12 months included the Short Physical Performance Battery (SPPB), the Functional Independence Measure (FIM), HRQoL (15D) and the Mini-Mental State Examination (MMSE).ResultsEligibility was screened among 520 persons; 300 met the inclusion criteria and were randomized. One person withdrew consent after randomization. A majority (75%) were women, 182 were pre-frail and 117 frail. The mean age was 82.5 (SD 6.3) years, SPPB 6.2 (2.6), FIM 108.8 (10.6) and MMSE 24.4 (3.1) points, with no significant differences between the study groups. Inverse associations between the severity of frailty vs. FIM scores and HRQoL (p < 0.001 for both) were found.ConclusionsOur participants showed marked physical frailty without major disabilities. The severity of frailty seems to be associated with impaired functional independence and HRQoL.Trial RegistrationClinicalTrials.gov NCT02305433.

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