• Prashant N Rao, Ojas Mainkar, Nitin Bansal, Neal Rakesh, Paul Haffey, Ivan Urits, Vwaire Orhurhu, Alan D Kaye, Richard D Urman, Amitabh Gulati, and Mark Jones.
• Department of Anesthesiology, New York-Presbyterian, Weill Cornell Medical College, 525 East 68th Street, Box 124, New York, NY, 10065, USA.
• Curr Pain Headache Rep. 2021 May 7; 25 (7): 43.

Purpose Of ReviewChronic pain continues to present a large burden to the US healthcare system. Neuropathic pain, a common class of chronic pain, remains particularly difficult to treat despite extensive research efforts. Current pharmacologic regimens exert limited efficacy and wide, potentially dangerous side effect profiles. This review provides a comprehensive, preclinical evaluation of the literature regarding the role of flavonoids in the treatment of neuropathic pain.Recent FindingsFlavonoids are naturally occurring compounds, found in plants and various dietary sources, which may have potential benefit in neuropathic pain. Numerous animal-model studies have demonstrated this benefit, including reversal of hyperalgesia and allodynia. Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-α, NF-κB, IL-1β, and IL-6. Flavonoids represent a potentially new treatment modality for neuropathic pain in preclinical models, though human clinical evidence is yet to be explored at this time.

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