• Styliani A Geronikolou, Athanasia Pavlopoulou, Dennis V Cokkinos, Flora Bacopoulou, and George P Chrousos.
• Clinical, Translational & Experimental Surgery Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
• Eur. J. Clin. Invest. 2021 Sep 1; 51 (9): e13578.

BackgroundThe polycystic ovary syndrome (PCOS) has genetic, epigenetic, metabolic and reproductive aspects, while its complex pathophysiology has not been conclusively deciphered.AimThe goal of this research was to screen the gene/gene products associated with PCOS and to predict any possible interactions with the highest possible fidelity.Materials And MethodsSTRING v10.5 database and a confidence level of 0.7 were used.ResultsA highly interconnected network of 48 nodes was created, where insulin (INS) appears to be the major hub. INS upstream and downstream defects were analysed and revealed that only the kisspeptin- and glucagon-coding genes were upstream of INS.ConclusionA metabolic dominance was inferred and discussed herein with its implications in puberty, obesity, infertility and cardiovascular function. This study, thus, may contribute to the resolution of a scientific conflict between the USA and EU definitions of the syndrome and/or provide a new P4 medicine approach.© 2021 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.

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