• Sarah Damanti, Giuseppe Alvise Ramirez, Enrica Paola Bozzolo, Patrizia Rovere-Querini, Rebecca De Lorenzo, Cristiano Magnaghi, Raffaella Scotti, Giuseppe Di Lucca, Alessandro Marinosci, Silvia Strada, Gaetano Di Terlizzi, Giordano Vitali, Sabina Martinenghi, Nicola Compagnone, Giovanni Landoni, and Moreno Tresoldi.
• Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
• Intern Med J. 2021 Nov 1; 51 (11): 181018151810-1815.

BackgroundCOVID-19 long-term sequelae are ill-defined since only a few studies have explored the long-term consequences of this disease so far.AimsTo evaluate the 6-month respiratory outcome and exercise capacity of COVID-19 acute respiratory failure (ARF) patients treated with continuous positive airway pressure (CPAP) during the first wave of the ongoing COVID-19 pandemic.MethodsA retrospective observational study included COVID-19 patients with ARF. Interventions included CPAP during hospitalisation and 6-month follow up. Frailty assessment was carried out through frailty index (FI), pO2 /FiO2 during hospitalisation and at follow up, respiratory parameters, 6-min walking test (6MWT) and the modified British Medical Research Council (mMRC) and Borg scale at follow up.ResultsMore than half of the patients had no dyspnoea according to the mMRC scale. Lower in-hospital pO2 /FiO2 correlated with higher Borg scale levels after 6MWT (ρ 0.27; P 0.04) at the follow-up visit. FI was positively correlated with length of hospitalisation (ρ 0.3; P 0.03) and negatively with the 6MWT distance walked (ρ -0.36; P 0.004).ConclusionsRobust and frail patients with COVID-19 ARF treated with CPAP outside the intensive care unit setting had good respiratory parameters and exercise capacity at 6-month follow up, although more severe patients had slightly poorer respiratory performance compared with patients with higher PaO2 /FiO2 and lower FI.© 2021 Royal Australasian College of Physicians.

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