• Athanasios A Konstantelias, Konstantinos A Polyzos, and Matthew E Falagas.
• 1 Alfa Institute of Biomedical Sciences (AIBS) , Athens, Greece .
• Surg Infect (Larchmt). 2016 Oct 1; 17 (5): 601-9.

BackgroundTo study the effectiveness of gentamicin-collagen sponges (GCS) for the prevention of surgical site infections (SSIs).MethodsA systematic search of the PubMed and Scopus databases was performed (up to April 2015) to identify randomized controlled trials evaluating the efficacy of GCS for the prevention of SSIs. A random effects model was applied.ResultsTwenty-one RCTs (8,472 patients) were included. Gentamicin-collagen sponges were associated with a lower risk of SSIs (risk ratio [RR] 0.65; 95% confidence interval [CI] 0.49-0.84). Based on Jadad scores, a lower risk for the development of SSI was presented in lower-quality studies (Jadad <3; RR 0.44; 95% CI 0.27-0.71), but no difference was observed in high-quality studies (Jadad ≥3; RR 0.77; 95% CI 0.58-1.02). No difference was observed in all-cause deaths in the GCS group compared with the control group (RR 0.77; 95% CI 0.56-1.06).ConclusionsWhen analyzing lower-quality studies or only clean procedures, GCS significantly reduced the risk of SSI. Further high-quality randomized studies are needed to confirm the benefit of GCS for lowering mortality rates.

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