• Dawn M Ehde, Jamie L Elzea, Aimee M Verrall, Laura E Gibbons, Amanda E Smith, and Dagmar Amtmann.
• Department of Rehabilitation Medicine, School of Medicine, University of Washington, Seattle, WA. Electronic address: ehde@uw.edu.
• Arch Phys Med Rehabil. 2015 Nov 1; 96 (11): 1945-58.e2.

ObjectiveTo evaluate the efficacy of a telephone-delivered self-management intervention for fatigue, pain, and depression in adults with multiple sclerosis (MS).DesignSingle-center, randomized (1:1), single-blind (outcome assessors), parallel-group trial with a primary endpoint of posttreatment (9-11 wk postrandomization) and long-term follow-up at 6 and 12 months.SettingTelephone-delivered across the United States.ParticipantsAdults with MS (N=163) with fatigue, chronic pain, and/or moderate depressive symptoms (age range, 25-76 y).InterventionsEight-week individual telephone-delivered self-management intervention (T-SM) (n=75) versus an 8-week individual telephone-delivered MS education intervention (T-ED) (n=88).Main Outcome MeasuresThe primary outcome was the proportion who achieved a ≥50% decrease in 1 or more symptoms-fatigue impact, pain interference, and/or depression severity. Secondary outcomes included continuous measures of pain, fatigue impact, depression, self-efficacy, activation, health-related quality of life, resilience, and affect.ResultsFor our primary outcome, 58% of those in the T-SM group and 46% of those in the T-ED group had a ≥50% reduction in 1 or more symptoms; this difference was not statistically significant (odds ratio, 1.50; 95% confidence interval, .77-2.93; P=.238). Participants in both groups significantly improved from baseline to posttreatment in primary and secondary outcome measures (P<.05). T-SM participants reported significantly higher treatment satisfaction and therapeutic alliance and greater improvements in activation, positive affect, and social roles. Improvements were generally maintained at 6 and 12 months.ConclusionsBoth interventions resulted in short- and long-term, clinically meaningful benefits. The study demonstrated that the telephone is an effective method for engaging participants in care and extending the reach of rehabilitation for individuals with MS.Copyright © 2015 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

38 keywords...

hide…