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Case Reports
Failure to over express MHC-CLASS-1 on muscle biopsy in a case of amyopathic juvenile dermatomyositis.
- L J McCann, C K C Li, H Varsani, L R Wedderburn, and C A Pilkington.
- Rheumatology Unit, Royal Liverpool Children's Hospital, Liverpool, UK. lisa.mccann@rlc.nhs.uk
- Clin Exp Rheumatol. 2007 Jan 1; 25 (1): 96-8.
AbstractThe concept of amyopathic dermatomyositis or dermatomyositis sine myositis, is contentious, particularly within paediatrics. We report an 8-year-old girl presenting with dermatological dermatomyositis without muscle weakness. Muscle biopsy changes are described, in particular, the absence of MHC class 1 over expression. This supports the concept of amyopathic dermatomyositis as a subgroup of juvenile dermatomyositis (JDM) and suggests that immunohistological analysis may be a valuable in excluding a myositic element in such cases.
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