• Mohammad Qrimli, Hamid Ebadi, Ari Breiner, Hafsah Siddiqui, Majed Alabdali, Alon Abraham, Leif E Lovblom, Bruce A Perkins, and Vera Bril.
• Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, Toronto General Hospital, University of Toronto University Health Network, 200 Elizabeth Street 5EC-309, Ontario, M5G 2C4, Canada.
• Muscle Nerve. 2016 Apr 1; 53 (4): 538-44.

IntroductionHigh-resolution ultrasonography (HRU) is a novel method that provides morphological information about peripheral nerves. We aimed to determine reference values for nerve cross-sectional area (CSA) on HRU.MethodsOne hundred healthy volunteers had HRU of median, radial, ulnar, fibular, tibial, sural, and superficial fibular nerves at defined sites. The CSA was measured and the effects of age, gender, and body mass index (BMI) were evaluated.ResultsCSA values in healthy subjects are described. CSA is larger in lower limb motor nerves than in sensory nerves at similar sites, and the CSA tends to be symmetrical. The strongest effect on CSA was for age, although gender and BMI had some effects.ConclusionsThis study provides normative values for HRU, and it suggests that further research with age- and gender-specific distributions must be a key priority in the development of HRU for use as a diagnostic test for peripheral nerve diseases.© 2015 Wiley Periodicals, Inc.

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