• Tsukasa Kamakura, Hiro Kawata, Ikutaro Nakajima, Yuko Yamada, Koji Miyamoto, Hideo Okamura, Takashi Noda, Kazuhiro Satomi, Takeshi Aiba, Hiroshi Takaki, Naohiko Aihara, Shiro Kamakura, Takeshi Kimura, and Wataru Shimizu.
• Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan; Division of Cardiology, Department of Cardiovascular Medicine, Kyoto University, Kyoto, Japan.
• J. Am. Coll. Cardiol. 2013 Oct 22; 62 (17): 1610-8.

ObjectivesThe aim of this study was to investigate the significance of non-type 1 anterior early repolarization (NT1-AER) combined with inferolateral early repolarization syndrome (ERS).BackgroundInferolateral ERS might be a heterogeneous entity, although it excludes type 1 Brugada syndrome (BS).MethodsOf 84 patients with spontaneous ventricular fibrillation, 31 ERS patients were divided into 2 groups. The ERS(A)-group consisted of inferolateral ER and NT1-AER--that is, notching or slurring with J-wave ≥ 1 mm at the end of QRS to early ST segment in any of V1 to V3 leads, in which the ST-T segment did not change to a coved pattern in the standard and high costal (second and third) electrocardiographic recordings even after drug provocation tests (n = 12). The other, ERS(B)-group, showed only inferolateral ER (n = 19). Clinical characteristics and outcomes were compared between the ERS groups, 40 patients with type-1 BS (BS-group), and 13 patients with idiopathic ventricular fibrillation lacking J-wave (IVF-group).ResultsVentricular fibrillation occurred during sleep or near sleep in 10 of 12 patients in ERS(A)-group and in 22 of 40 patients in BS-group but in 2 of 19 patients in ERS(B)-group and in 1 of 13 patients in IVF-group (ERS[A] vs. ERS[B], p < 0.0001). Ventricular fibrillation recurrence was significantly higher in ERS(A)-group (58%), particularly in patients with J waves in the high lateral lead, and BS-group (55%), compared with ERS(B)-group (11%) and IVF-group (15%) (ERS[A] vs. ERS[B], p = 0.012).ConclusionsInferolateral ERS comprises heterogeneous ER subtypes with and without NT1-AER. Coexistence of NT1-AER was a key predictor of poor outcome in patients with ERS.Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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