• Jelena Kornej, Gerhard Hindricks, Amitava Banerjee, Arash Arya, Philipp Sommer, Sascha Rolf, Daniela Husser, Gregory Y H Lip, and Andreas Bollmann.
• Department of Electrophysiology, Heart Center, University of Leipzig, Leipzig, Germany Centre for Cardiovascular Sciences, University of Birmingham, City Hospital, Birmingham, UK.
• Heart. 2015 Jan 1; 101 (2): 126-31.

BackgroundRenal impairment is associated with poor prognosis in the setting of atrial fibrillation (AF). While AF catheter ablation is an effective treatment modality for AF burden reduction and improvement of symptoms, changes in renal function after catheter ablation and their association with rhythm outcome have not been studied in a large contemporary AF ablation cohort.ObjectiveTo determine the association between CHADS2 and CHA2DS2-VASc scores and arrhythmia recurrences with changes in renal function following AF catheter ablation.MethodsEstimated glomerular filtration rate (eGFR) was estimated using the Chronic Kidney Disease Epidemiology Collaboration equation at baseline and during follow-up in 783 patients undergoing de novo AF catheter ablation. Complete rhythm follow-up was achieved in 626 patients (80%) using serial 7-day Holter ECG.ResultsThe study population (n=783, 61±10 years, 64% men, 57% paroxysmal AF) was followed up at median 20 (IQR 12-27) months. Baseline eGFR correlated with CHADS2 (β=-0.258, p<0.001) and CHA2DS2-VASc scores (β=-0.434, p<0.001). On multivariable analyses, eGFR changes were associated with AF recurrences (B=-0.136, p=0.014), CHADS2 (B=-0.062, p=0.035) and CHA2DS2-VASc scores (B=-0.057, p=0.003).ConclusionsIn patients after AF catheter ablation, eGFR changes during mid-term follow-up are associated with AF recurrences, CHADS2 and CHA2DS2-VASc scores.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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