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Ann Acad Med Singap · Nov 1998
Case ReportsA case report of heparin resistance due to acquired antithrombin III deficiency.
- C K Leong and B C Ong.
- Department of Anaesthesia and Surgical Intensive Care, Singapore General Hospital, Singapore.
- Ann Acad Med Singap. 1998 Nov 1; 27 (6): 877-9.
AbstractA case of heparin resistance and its management during cardiopulmonary bypass is reported. A patient with a history of post-infarct angina and arrhythmias was treated with intravenous heparin infusion for five days prior to myocardial revascularisation surgery. He required 13,500 IU/kg of heparin to increase his activated clotting time to a therapeutic level for safe institution of cardiopulmonary bypass. This phenomenon of heparin resistance was postulated to be due to consumption of circulating antithrombin III as a result of prior heparinisation. Treatment with fresh frozen plasma restored heparin effectiveness.
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