• Monica B Pagano, Guido Cataife, Kleber Yotsumoto Fertrin, Terry Gernsheimer, R Hess John J 0000-0001-8596-4420 Transfusion Medicine Division, Laboratory Medicine, University of Washington, Seattle, Washington, USA. , Elizabeth Staley, Christine Clark, Nina Senn, Erin Tuott, and Hamilton C Tsang.
• Transfusion Medicine Division, Laboratory Medicine, University of Washington, Seattle, Washington, USA.
• Transfusion. 2020 Dec 1; 60 (12): 2859-2866.

BackgroundThis report evaluates hospital blood use trends during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, and identifies factors associated with the need for transfusion and risk of death in patients with coronavirus 2019 (COVID-19).MethodsOverall hospital blood use and medical records of adult patients with COVID-19 were extracted for two institutions. Multivariate logistic regression models were conducted to estimate associations between the outcomes transfusion and mortality and patient factors.ResultsDaily blood use decreased compared to pre-COVID-19 levels; the effect was more significant for platelets (29% and 34%) compared to red blood cells (25% and 20%) at the two institutions, respectively. Surgical and oncologic services had a decrease in average daily use of platelets of 52% and 30%, and red blood cells of 39% and 25%, respectively. A total of 128 patients with COVID-19 were hospitalized, and 13 (10%) received at least one transfusion due to anemia secondary to chronic illness (n = 7), recent surgery (n = 3), and extracorporeal membrane oxygenation (n = 3). Lower baseline platelet count and admission to the intensive care unit were associated with increased risk of transfusion. The blood group distribution in patients with COVID-19 was 37% group O, 40% group A, 18% group B, and 5% group AB. Non-type O was not associated with increased risk of mortality.ConclusionThe response to the SARS-CoV-2 pandemic included changes in routine hospital operations that allowed for the provision of a sufficient level of care for patients with and without COVID-19. Although blood type may play a role in COVID-19 susceptibility, it did not seem to be associated with patient mortality.© 2020 AABB.

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