Glucocorticoids for Management of Polymyalgia Rheumatica and

Rheum. Dis. Clin. North Am. · Feb 2016

Review

Glucocorticoids for Management of Polymyalgia Rheumatica and Giant Cell Arteritis.

Diagnosis of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) is based on typical clinical, histologic, and laboratory features. Ultrasonographic imaging in PMR with assessment especially of subdeltoid bursitis can aid in diagnosis and in following response to treatment. ⋯ Methotrexate may be used in patients at high risk for glucocorticoid adverse effects and patients with frequent relapse or needing protracted therapy. Other therapeutic approaches including interleukin 6 antagonists are under evaluation.

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- Eric L Matteson, Frank Buttgereit, Christian Dejaco, and Bhaskar Dasgupta.
- Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55902, USA; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55902, USA. Electronic address: Matteson.eric@mayo.edu.
- Rheum. Dis. Clin. North Am. 2016 Feb 1; 42 (1): 75-90, viii.
AbstractDiagnosis of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) is based on typical clinical, histologic, and laboratory features. Ultrasonographic imaging in PMR with assessment especially of subdeltoid bursitis can aid in diagnosis and in following response to treatment. In GCA, diagnosis and disease activity are supported with ultrasonographic, MRI, or [(18)F]fluorodeoxyglucose PET evaluation of large vessels. Glucocorticoids are the primary therapy for PMR and GCA. Methotrexate may be used in patients at high risk for glucocorticoid adverse effects and patients with frequent relapse or needing protracted therapy. Other therapeutic approaches including interleukin 6 antagonists are under evaluation. Copyright © 2016 Elsevier Inc. All rights reserved.

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Glucocorticoids for Management of Polymyalgia Rheumatica and Giant Cell Arteritis.

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