• Matthew P Kirschen, Daniel J Licht, Jennifer Faerber, Antara Mondal, Kathryn Graham, Madeline Winters, Ramani Balu, Ramon Diaz-Arrastia, Robert A Berg, Alexis Topjian, and Arastoo Vossough.
• From the Department of Anesthesiology and Critical Care Medicine (M.P.K., K.G., M.W., R.A.B., A.T.), Department of Pediatrics (M.P.K., D.J.L., R.A.B., A.T.), Health Analytics Unit (J.F., A.M.), and Department of Radiology (A.V.), Children's Hospital of Philadelphia; and Department of Neurology (M.P.K., D.J.L., R.B., R.D.-A.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia. kirschenm@chop.edu.
• Neurology. 2021 Feb 2; 96 (5): e719-e731.

ObjectiveTo determine the association between the extent of diffusion restriction and T2/fluid-attenuated inversion recovery (FLAIR) injury on brain MRI and outcomes after pediatric out-of-hospital cardiac arrest (OHCA).MethodsDiffusion restriction and T2/FLAIR injury were described according to the pediatric MRI modification of the Alberta Stroke Program Early Computed Tomography Score (modsASPECTS) for children from 2005 to 2013 who had an MRI within 14 days of OHCA. The primary outcome was unfavorable neurologic outcome defined as ≥1 change in Pediatric Cerebral Performance Category (PCPC) from baseline resulting in a hospital discharge PCPC score 3, 4, 5, or 6. Patients with unfavorable outcomes were further categorized into alive with PCPC 3-5, dead due to withdrawal of life-sustaining therapies for poor neurologic prognosis (WLST-neuro), or dead by neurologic criteria.ResultsWe evaluated MRI scans from 77 patients (median age 2.21 [interquartile range 0.44, 13.07] years) performed 4 (2, 6) days postarrest. Patients with unfavorable outcomes had more extensive diffusion restriction (median 7 [4, 10.3] vs 0 [0, 0] regions, p < 0.001) and T2/FLAIR injury (5.5 [2.3, 8.2] vs 0 [0, 0.75] regions, p < 0.001) compared to patients with favorable outcomes. Area under the receiver operating characteristic curve for the extent of diffusion restriction and unfavorable outcome was 0.96 (95% confidence interval [CI] 0.91, 0.99) and 0.92 (95% CI 0.85, 0.97) for T2/FLAIR injury. There was no difference in extent of diffusion restriction between patients who were alive with an unfavorable outcome and patients who died from WLST-neuro (p = 0.11).ConclusionsMore extensive diffusion restriction and T2/FLAIR injury on the modsASPECTS score within the first 14 days after pediatric cardiac arrest was associated with unfavorable outcomes at hospital discharge.© 2020 American Academy of Neurology.

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