• Anna Lena Fisse, Aristeidis H Katsanos, Ralf Gold, Christos Krogias, and Kalliopi Pitarokoili.
• Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
• Eur. J. Neurol. 2021 Jul 1; 28 (7): 2313-2318.

Background And PurposeMeasurement of the cross-sectional area (CSA) of peripheral nerves using ultrasound is useful in the evaluation of focal lesions such as entrapment syndromes and inflammatory polyneuropathies. We performed a systematic review and meta-analysis of published CSA reference values for lower extremity nerves.MethodsWe included available-to-date nerve ultrasound studies on healthy adults and provide meta-analysis for CSA of the following nerves: fibular nerve at fibular head, popliteal fossa; tibial nerve at popliteal fossa, malleolus; and sural nerve at the level of the two heads of gastrocnemius muscle. We report regression and correlation analyses for age, gender distribution, height, weight, and geographic continent.ResultsWe included 16 studies with 1001 healthy volunteers (mean age = 47.9 years) and 4023 examined nerve sites. Calculated mean pooled CSA of fibular nerve at fibular head was 8.4 mm2 (95% confidence interval [CI] = 6.8-9.9 mm2 , n = 1166), at popliteal fossa was 7.9 mm2 (95% CI = 6.6-9.2 mm2 , n = 995), of tibial nerve at popliteal fossa was 25.9 mm2 (95% CI = 17.5-34.4 mm2 , n = 771), at malleolus was 10.0 mm2 (95% CI = 7.7-12.4 mm2 , n = 779), and of sural nerve was 2.4 mm2 (95% CI = 1.7-3.1 mm2 , n = 312). Substantial heterogeneity across studies (I2  > 50%) was found only for tibial nerve at popliteal fossa. Subgroup analysis revealed a lower CSA of tibial nerve at popliteal fossa and sural nerve in studies conducted in Europe than in North America and New Zealand.ConclusionsWe provide the first meta-analysis on CSA reference values for the lower extremities with no or low heterogeneity of reported CSA values in all nerve sites except tibial nerve at popliteal fossa. Our data facilitate the goal of an international standardized evaluation protocol.© 2021 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.

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