• Dmitry Druzhinin, Еugeniia Naumova, and Sergey Nikitin.
• Yaroslavl State Medical University, Department of Neuropathology, Russian Federation.
• Muscle Nerve. 2019 Dec 1; 60 (6): 757-761.

BackgroundThe objective of the study was to determine the reference values for cross-sectional area (CSA) of the nerves in healthy subjects between the age of 2 and 30 years.MethodsHigh-resolution ultrasonography (HRU) of the median, ulnar, tibial, sural, peroneal and spinal nerves C5-C7 was performed in 72 healthy subjects.ResultsThe CSA of peripheral nerves demonstrated an age-dependent increase in size at all measurement sites in children up to around 14 years of age. This was most pronounced for large lower limb nerves and least for small nerves. Intra-nerve and inter-nerve variability of nerve CSA did not change with age.ConclusionsThis study provides normative values for HRU of peripheral nerves in children and young adults. Adult reference values should not be used for children under the age of 14 years.© 2019 Wiley Periodicals, Inc.

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