• Xiaojun Yuan, Mengjie Tang, Qi Sheng, Xiaodong Zhu, and Qin Zhang.
• Department of Pediatric Hematology/Oncology, Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
• SAGE Open Med Case Rep. 2014 Jan 1; 2: 2050313X14531220.

ObjectiveLangerhans cell histiocytosis is an unusual disorder of unknown etiology with heterogeneous clinical behaviors and variable outcomes. It can involve one or more organs or systems, but to our best knowledge, parotid glands involvement in Langerhans cell histiocytosis is extremely rare in English literature.MethodWe report a 13-month-old girl who presented with bilateral parotid swelling as presenting symptom. She was misdiagnosed for 4 months, but final diagnosis was multisystem Langerhans cell histiocytosis.ResultAfter being treated for 18 months, the patient acquired complete remission and attained similar growth status to other healthy children.ConclusionLangerhans cell histiocytosis may involve any organ; in patients with parotid enlargement, Langerhans cell histiocytosis should be kept in mind in the differential diagnoses. We emphasize the importance of biopsy for histologic evaluation as soon as possible and even repeatedly if initial results are negative for Langerhans cell histiocytosis.

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