• J. Hosp. Infect. · Apr 2021

    Evaluation of procalcitonin as a contribution to antimicrobial stewardship in SARS-CoV-2 infection: a retrospective cohort study.

    • E J Williams, L Mair, T I de Silva, D J Green, P House, K Cawthron, C Gillies, J Wigfull, H Parsons, and D G Partridge.
    • Department of Microbiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK; South Yorkshire Regional Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK. Electronic address: emma.williams43@nhs.net.
    • J. Hosp. Infect. 2021 Apr 1; 110: 103-107.

    AbstractIt can be a diagnostic challenge to identify patients with coronavirus disease 2019 in whom antibiotics can be safely withheld. This study evaluated the effectiveness of a guideline implemented at Sheffield Teaching Hospitals NHS Foundation Trust that recommends withholding antibiotics in patients with low serum procalcitonin (PCT), defined as ≤0.25 ng/mL. Results showed reduced antibiotic consumption in patients with PCT ≤0.25 ng/mL with no increase in mortality, alongside a reduction in subsequent carbapenem prescriptions during admission. The results support the effectiveness of this guideline, and further research is recommended to identify the optimal cut-off value for PCT in this setting.Crown Copyright © 2021. Published by Elsevier Ltd. All rights reserved.

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