• Clin. Orthop. Relat. Res. · Nov 1992

    Comparative Study

    In vitro elution characteristics of commercially and noncommercially prepared antibiotic PMMA beads.

    • C L Nelson, F M Griffin, B H Harrison, and R E Cooper.
    • Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock.
    • Clin. Orthop. Relat. Res. 1992 Nov 1 (284): 303-9.

    AbstractThe successful treatment of osteomyelitis with commercially prepared gentamicin-polymethylmethacrylate (PMMA) (Septopal) beads and surgical debridement has led to the use of this technique in the United States. However, commercially prepared gentamicin-PMMA beads are not currently available to orthopedic surgeons in the United States. Therefore, these surgeons commonly manufacture their own antibiotic-containing cement beads in the operating room at the time of surgery. There is little data that compare the antibiotic elution characteristics of such preparations to commercially prepared gentamicin-PMMA beads. This study compares the measured amount of antibiotic elution of either gentamicin or tobramycin from laboratory manufactured Zimmer, Simplex, or Palacos beads to commercially prepared gentamicin-PMMA (Septopal) beads. During a 30-day study period, commercially prepared gentamicin-PMMA beads eluted more total antibiotic and maintain higher concentrations than did antibiotic acrylic composites manufactured in the authors' laboratory.

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