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- A Carsin, T Romain, S Ranque, M Reynaud-Gaubert, J-C Dubus, J-L Mège, and J Vitte.
- Aix-Marseille Univ, APHM, Hôpital Timone Enfants, Pneumo-pédiatrie, Centre de Ressources et de Compétences en Mucoviscidose, Marseille, France.
- Allergy. 2017 Nov 1; 72 (11): 1632-1642.
AbstractA wide spectrum of pathological conditions may result from the interaction of Aspergillus fumigatus and the immune system of its human host. Allergic bronchopulmonary aspergillosis is one of the most severe A. fumigatus-related diseases due to possible evolution toward pleuropulmonary fibrosis and respiratory failure. Allergic bronchopulmonary aspergillosis occurs almost exclusively in cystic fibrosis or asthmatic patients. An estimated 8%-10% of patients with cystic fibrosis experience this condition. The diagnosis of allergic bronchopulmonary aspergillosis relies on criteria first established in 1977. Progress in the understanding of host-pathogen interactions in A. fumigatus and patients with cystic fibrosis and the ongoing validation of novel laboratory tools concur to update and improve the diagnosis of allergic bronchopulmonary aspergillosis.© 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
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