• SpringerPlus · Jan 2016

    Measuring serum matrix metalloproteinase-9 levels in peripheral blood after subarachnoid hemorrhage to predict cerebral vasospasm.

    • Aykut Akpinar, Necati Ucler, Uzay Erdogan, Serhat S Baydin, Abuzer Gungor, and Bekir Tugcu.
    • Department of Neurosurgery, Adiyaman University Education and Research Hospital, 02200 Adiyaman, Turkey.
    • Springerplus. 2016 Jan 1; 5 (1): 1153.

    PurposeWe aimed to investigate serum levels of matrix metalloproteinase-9 in both subarachnoid hemorrhage and control groups for prediction of cerebral vasospasm in this study.MethodsVenous serum matrix metalloproteinase-9 levels were prospectively measured four times (days 1, 3, 7, and 14) for 34 consecutive patients with subarachnoidal hemorrhage (n = 27) and for elective aneurysm clipping (control, n = 7).ResultsVasospasm developed in 11/34 (32.4 %) patients between 3 and 10 days after subarachnoid hemorrhage (median 5.58 days), mean peak serum matrix metalloproteinase-9 compared with the non-vasospasm cohort. Matrix metalloproteinase-9 levels were higher in subarachnoid hemorrhage patients than in the controls.ConclusionIncreased serum matrix metalloproteinase-9 could be an accurate biomarker to predict the onset of cerebral vasospasm after subarachnoid hemorrhage.

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