• Vascular pharmacology · Mar 2013

    Review

    Rho GTPases in pulmonary vascular dysfunction.

    • Elisabeth M Storck and Beata Wojciak-Stothard.
    • Centre for Pharmacology and Therapeutics, Imperial College London, UK.
    • Vascul. Pharmacol. 2013 Mar 1; 58 (3): 202-10.

    AbstractRho proteins, best known for their regulatory role in actin dynamics, stimulate a variety of processes important in the control of vascular function, including morphogenesis, migration, cell proliferation and adhesion, cell survival, gene expression, vesicle transport and microparticle formation. Rho GTPases have been implicated in several pulmonary vascular pathologies. Here we give an overview of the current knowledge of the role of Rho GTPases in vascular dysfunction, and pulmonary diseases such as pulmonary hypertension, pulmonary embolism, chronic obstructive pulmonary disease, acute lung injury and acute respiratory distress syndrome.Copyright © 2012 Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…