• Francesco Della Gatta, Eleonora Lacorte, Elisa Fabrizi, Giulia Remoli, Virginia Cipollini, Fernanda Troili, Nicola Vanacore, and Franco Giubilei.
• Department of Neuroscience, Mental Health, and Sense Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University, Rome, Italy - francesco.dellagatta@uniroma1.it.
• Minerva Med. 2021 Aug 1; 112 (4): 448-455.

IntroductionPhysical activity has been included in the list of twelve modifiable risk factors for dementia, despite conflicting results from observational and controlled studies. In particular it is not clear whether physical inactivity near the time of dementia diagnosis is a consequence or cause of dementia. We review all available studies reporting the possible association between having engaged in PA before 60 years of age and the risk of dementia.Evidence AcquisitionWe performed a systematic review based on the methodology reported in the Cochrane handbook for systematic reviews and following the PRISMA statement. Bibliographic searches were carried out on the databases PubMed, ISI Web of Science and the Cochrane Database of Systematic Reviews. Further references were retrieved from published systematic reviews on the same topic. Included studies were assessed using the Newcastle Ottawa scale.Evidence SynthesisThe bibliographic search yielded 1381 records. A total of 11 studies were included. Three of the included studies were case control studies, while the remaining 8 were cohort studies The overall quality of included studies was high. However, clinical criteria for the diagnosis of dementia, criteria to define and measure and PA and time-reference of exposure were heterogeneous, with some studies considering specific age range of exposure, and other reports dealing with more generic "adult age."ConclusionsThis review suggests that there is insufficient evidence to conclude whether PA in early life may affect the incidence of dementia in later life. Studies in this field are very complicated and recognizing the impact of PA in early life given all the confounding factors is very difficult. Further studies are warranted. In these studies, it will be crucial to define the type, quantity and intensity of PA as well as to stratify analysis by sex, cultures and social classes.

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