• Ir J Med Sci · Apr 2022

    Anal squamous cell carcinoma: a retrospective case series.

    • Orla Anne Houlihan, Orla Monaghan, Siobhra O'Sullivan, Killian Nugent, Mary Dunne, Paul Neary, Ronan Cahill, Brian Mehigan, Deborah A McNamara, Osama Salib, Charles Gillham, Gerard McVey, Clare Faul, Moya Cunningham, John Armstrong, and O'NeillBrian D PBDPDepartment of Radiation Oncology, St Luke's Radiation Oncology Network, Dublin, Ireland..
    • Department of Radiation Oncology, St Luke's Radiation Oncology Network, Dublin, Ireland. orla.houlihan@slh.ie.
    • Ir J Med Sci. 2022 Apr 1; 191 (2): 681-686.

    BackgroundAnal cancer is a relatively rare cancer with 660 cases diagnosed in 2000-2015 in Ireland (1). The current standard treatment is radical chemoradiotherapy (CRT). The aim of our study was to review the treatment and outcomes of patients with localised anal squamous cell carcinoma (SCC), who received radical treatment in our radiation oncology network between 2008 and 2014 inclusive.MethodsData were collected retrospectively from ARIA® oncology information system and patient charts. Statistical analyses were performed using IBM® SPSS® statistical software version 25.0.ResultsSeventy-nine cases of anal SCC were identified. Mean age of patients at commencement of radiotherapy (RT) was 60.2 years (standard deviation: 13.1 years). The most common total RT dose was 50.4 Gy in 28 fractions (N = 58; 73.4%). Median follow-up was 5.6 years. Two (2.6%) patients had persistent disease, seventeen (21.8%) patients developed loco-regional recurrence and nine (11.5%) patients developed solid organ metastases, four of whom had complete treatment response at the primary site. Eight patients underwent salvage anal surgery following completion of RT. Median overall survival was 10.5 years (95% confidence interval (CI) 5.1-15.8 years), median loco-regional relapse-free survival was 10.4 years (95% CI 4.4-16.3 years) and median disease-free survival was 9.3 years (95% CI 6.3-12.2 years).ConclusionOur study demonstrates that treatment for anal SCC and outcomes following definitive CRT in Ireland during the study period were comparable to international standards.© 2021. Royal Academy of Medicine in Ireland.

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