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Clin Exp Gastroenterol · Jan 2018
ReviewPostoperative pancreatic fistula: a review of traditional and emerging concepts.
- Christopher B Nahm, Saxon J Connor, Jaswinder S Samra, and Anubhav Mittal.
- Upper Gastrointestinal Surgical Unit, Royal North Shore Hospital, Sydney, Australia.
- Clin Exp Gastroenterol. 2018 Jan 1; 11: 105-118.
AbstractPostoperative pancreatic fistula (POPF) remains the major cause of morbidity after pancreatic resection, affecting up to 41% of cases. With the recent development of a consensus definition of POPF, there has been a large number of reports examining various risk factors, prediction models, and mitigation strategies for this costly complication. Despite these strategies, the rates of POPF have not significantly diminished. Here, we review the literature and evidence regarding both traditional and emerging concepts in POPF prediction, prevention, and management. In particular, we review the evidence for the association between postoperative pancreatitis and POPF, and present a novel proposed mechanism for the development of POPF.
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