• Romain E Kania, Dana M Hartl, Cécile Badoual, Christine Le Maignan, and Daniel F Brasnu.
• Department of Otorhinolaryngology-Head and Neck Surgery, Hôpital Européen Georges Pompidou, 20, rue Leblanc, 75015 Paris, France.
• Head Neck. 2005 Mar 1; 27 (3): 258-62.

BackgroundMucosa-associated lymphoid tissue (MALT) lymphoma is usually associated with a chronic inflammatory disease from which lymphoid tissue of MALT type arises as a prerequisite for lymphoma proliferation. No well-characterized chronic inflammatory process has been identified in the larynx.MethodsWe report a case of primary MALT lymphoma of the larynx associated with extraesophageal reflux, chronic laryngitis, and gastric Helicobacter pylori infection, raising the issue of its physiopathology and treatment.ResultsTreatment of this MALT lymphoma of the larynx consisted of complete surgical excision associated with omeprazole, amoxicillin, and clarithromycin. No evidence of disease was observed after 24 months of follow-up.ConclusionsWe may assume that chronic laryngitis could be a precursor to MALT lymphoma. This case is the first one to our knowledge of a primary MALT lymphoma of the larynx treated with conservative management combining surgical excision, reflux therapy, and eradication of gastric H. pylori infection.2005 Wiley Periodicals, Inc.

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