• Proteomics · Apr 2018

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    Proteomics with Mass Spectrometry Imaging: Beyond Amyloid Typing.

    • Francesca Lavatelli and Giampaolo Merlini.
    • Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
    • Proteomics. 2018 Apr 1; 18 (7): e1700353.

    AbstractDetection and typing of amyloid deposits in tissues are two crucial steps in the management of systemic amyloidoses. The presence of amyloid deposits is routinely evaluated through Congo red staining, whereas proteomics is now a mainstay in the identification of the deposited proteins. In article number 1700236, Winter et al. [Proteomics 2017, 17, Issue 22] describe a novel method based on MALDI-MS imaging coupled to ion mobility separation and peptide filtering, to detect the presence of amyloid in histology samples and to identify its composition, while preserving the spatial distribution of proteins in tissues.© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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