• Cutis · Sep 1996

    Review

    The non-Langerhans' cell histiocytoses in childhood.

    • W H Burgdorf and B Zelger.
    • Department of Dermatology, Ludwig Maximilian University, Munich, Germany.
    • Cutis. 1996 Sep 1; 58 (3): 201-7.

    AbstractThe cutaneous histiocytoses are best divided in the Langerhans' cell histiocytoses and non-Langerhans' cell histiocytoses. In the former group, the cells react with S100 and CD1a antibodies, while in the latter group they express a variety of macrophage markers. Xanthogranuloma is a frequent childhood tumor and the only common non-Langerhans' cell histiocytosis. Xanthogranulomas contain a mixture of several different types of histiocytes that also appear in more pure forms as both solitary tumors and disseminated processes. The varying histiocyte morphology provides a unifying concept for non-Langerhans' cell histiocytoses.

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