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- Paolo Bonanni, Catherine Cohet, Susanne K Kjaer, Nina B Latham, Paul-Henri Lambert, Keith Reisinger, and Richard M Haupt.
- University of Florence, Florence, Italy.
- Vaccine. 2010 Jul 5; 28 (30): 4719-30.
AbstractGARDASIL has been shown to reduce the incidence of pre-cancerous cervical, vulvar, and vaginal lesions, and external genital warts causally related to HPV6/11/16/18. Because of its expected public health benefit on reduction of cervical cancer and other HPV-related diseases, this vaccine has been rapidly implemented in the routine vaccination programs of several countries. It is therefore essential to assess its impact and safety through post-licensure surveillance programs. Here, we present a summary of 16 post-licensure safety and impact studies across 20 countries. These studies address general safety, including autoimmune disorders, long-term effectiveness, and type replacement. A summary of the surveillance efforts of the Unites States Centers for Disease Control and Prevention can be found in the accompanying article by Markowitz et al.Copyright 2010 Elsevier Ltd. All rights reserved.
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