• Lakmini Bulathsinhala, Nevaashni Eleangovan, Liam G Heaney, Andrew Menzies-Gow, Peter G Gibson, Matthew Peters, Mark Hew, van Boven Job F M JFM Department of General Practice, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groning, Lauri Lehtimäki, Eric van Ganse, Manon Belhassen, Erin S Harvey, Luis Perez de Llano, Anke H Maitland-van der Zee, Nikolaos G Papadopoulos, J Mark FitzGerald, Celeste Porsbjerg, G Walter Canonica, Vibeke Backer, Chin Kook Rhee, Verhamme Katia M C KMC Erasmus Medical Center, Rotterdam, The Netherlands., Roland Buhl, Borja G Cosio, Victoria Carter, Chris Price, Thao Le, Martina Stagno d'Alcontres, Gokul Gopalan, Trung N Tran, and David Price.
• Optimum Patient Care, Cambridge, UK.
• J Allergy Clin Immunol Pract. 2019 Feb 1; 7 (2): 578-588.e2.

BackgroundThe lack of centralized data on severe asthma has resulted in a scarcity of information about the disease and its management. The development of a common data collection tool for the International Severe Asthma Registry (ISAR) will enable standardized data collection, subsequently enabling data interoperability.ObjectivesTo create a standardized list of variables for the first international registry for severe asthma via expert consensus.MethodsA modified Delphi process was used to reach consensus on a minimum set of variables to capture in ISAR: the core variables. The Delphi panel brought together 27 international experts in the field of severe asthma research. The process consisted of 3 iterative rounds. In each round, all Delphi panel members were issued an electronic ISAR Delphi workbook to complete and return to the ISAR Delphi administrator. Workbooks and result summaries were anonymously distributed by the Delphi administrator to all panel members at subsequent rounds. Finalization of the core variable list was facilitated by 2 face-to-face meetings.ResultsOf the initial 747 selected variables, the Delphi panel reached a consensus on 95. The chosen variables will allow severe asthma to be assessed against patient demographics and medical history, patient-reported outcomes, diagnostic information, and clinical characteristics. Physician-reported outcomes such as nonadherence and information about treatment and management strategies will also be recorded.ConclusionsThis is the first global attempt to generate an ISAR using a common set of core variables to ensure that data collected across all participating countries are standardized.Copyright © 2018 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

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