• Curr Med Res Opin · Jul 2021

    Validity and reliability of the QLQ-MY20 module for assessing the health-related quality of life in Brazilians with multiple myeloma.

    • Jéssica Soares Malta, Lívia Pena Silveira, Paula Lana de Miranda Drummond, Naiane Lima Costa, Dos SantosRoberta Márcia MarquesRMM0000-0003-1844-6628Ezequiel Dias Foundation - Funed, Belo Horizonte, Brazil., Ilka Afonso Reis, Adriano Max Moreira Reis, and de PáduaCristiane Aparecida MenezesCAM0000-0001-7083-3188Department of Social Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil..
    • Department of Social Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
    • Curr Med Res Opin. 2021 Jul 1; 37 (7): 1163-1169.

    PurposeMultiple myeloma (MM) is a rare but treatable hematological cancer, which makes the health-related quality of life (HRQoL) an important patient-report outcome measure in clinical studies. The Quality of Life Questionnaire Multiple Myeloma Module (QLQ-MY20) was developed by the European Organization for Research and Treatment of Cancer (EORTC) to measure HRQoL in people with MM. However, the Brazilian Portuguese version of QLQ-MY20 has not yet been validated for Brazil. This study aimed to evaluate the validity and reliability of the instrument for application in Brazilian patients with MM.MethodsThis is a cross-sectional methodological study with patients seen in health services in Belo Horizonte, Brazil. The variables were collected through face-to-face interviews with the QLQ-MY20 instrument and complemented with data from medical records. Content validity analyses (content validity coefficient [CVC]; correctness ratio), convergent and divergent validity (Spearman's correlation coefficient [CC]), internal consistency, and temporal reproducibility (test-retest; intraclass correlation coefficient [ICC]) were performed.Results225 patients were included and 71.1% were older than 60. The analysis of the judging committee showed adequate content validity. We observed mainly a good internal consistency of the items and good discrimination power in the convergent and divergent validity. High ICC values were observed through the test-retest, and there was no difference in the scores between the two moments, which shows good temporal stability of the instrument.ConclusionThe study allowed us to conclude that the Brazilian version of the QLQ-MY20 module is valid and reliable, and thus suitable for application in Brazilians living with MM.

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