• Rubina Malik, Dhanya Mullassery, Maren Kleine-Brueggeney, Ayad Atra, Anami Gour, Robin Sunderland, and Bruce Okoye.
• Department of Paediatric Oncology, St George's Hospital NHS Trust, London, UK.
• J. Pediatr. Surg. 2019 Feb 1; 54 (2): 251-254.

ObjectiveThe objective of this study was to report our multidisciplinary diagnostic approach for patients with anterior mediastinal masses (AMM).MethodsA retrospective review of patients with AMM at a tertiary pediatric surgical oncology centre (January 2011-December 2016) was performed. We analyzed data on clinical presentation, mode of tissue diagnosis, anesthetic techniques, and complications.ResultsOf the 44 patients admitted with AMM (median age 11 years, 27 males and 17 females), 22 had respiratory symptoms. Imaging revealed tracheobronchial compression in 26 children. Twenty patients had a lymph node biopsy. Ten patients had image-guided core biopsy of the mediastinal mass, and 2 had mediastinoscopic biopsy of a paratracheal lymph node. One patient with likely recurrence of a relapsed metastatic ethmoid carcinoma did not have a biopsy. The diagnosis was made from alternative tissues, such as pleural fluid in 4 and peripheral blood in 7 patients. Twenty-five anesthetics were assessed, as 14 patients required no or only local anesthesia, and 5 had unavailable anesthetic notes. Eighteen of 25 patients were anesthetized maintaining spontaneous breathing, mostly by means of ketamine sedation. There were no major anesthetic complications.ConclusionSafe tissue diagnosis of anterior mediastinal masses can be obtained by a personalized multidisciplinary approach. Use of alternative tissues, local anesthesia, and ketamine sedation help minimize the need for general anesthesia, muscle paralysis, and controlled ventilation.Level Of EvidenceIV (Case Series with no Comparison Group).Copyright © 2018. Published by Elsevier Inc.

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