• Am. J. Med. Sci. · Mar 2001

    Case Reports

    Microscopic polyangiitis presenting as idiopathic pulmonary fibrosis: is anti-neutrophilic cytoplasmic antibody testing indicated?

    • I A Mansi, A Opran, D Sondhi, R Ayinla, and F Rosner.
    • Department of Medicine, Queens Hospital Center, Jamaica, New York 11432, USA.
    • Am. J. Med. Sci. 2001 Mar 1; 321 (3): 201-2.

    AbstractWe report a 55-year old woman with microscopic polyangiitis who presented with idiopathic pulmonary fibrosis and 1 year later developed hematuria and proteinuria. She had a high serum level of perinuclear anti-neutrophilic cytoplasmic antibodies. Renal angiogram was normal. The diagnosis of microscopic polyangiitis was confirmed by renal biopsy, which showed pauci-immune crescentic glomerulonephritis. The patient received immunosuppressive therapy and improved markedly. Consideration of small vessel vasculitis is important in the differential diagnosis of idiopathic pulmonary fibrosis.

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