• Ann. N. Y. Acad. Sci. · Jan 1988

    Review

    Mechanisms of virus-induced demyelination and remyelination.

    • M Rodriguez.
    • Department of Neurology and Immunology, Mayo Clinic and Research Foundation, Rochester, Minnesota.
    • Ann. N. Y. Acad. Sci. 1988 Jan 1; 540: 240-51.

    AbstractViral models of demyelination and remyelination provide important clues to the pathogenesis of multiple sclerosis. Determining the precise viral polypeptides recognized by T cells during the demyelinating process will be important in understanding the mechanisms of viral-induced myelin destruction. Isolation, purification, and characterization of factors that promote remyelination and proliferation of oligodendrocytes may provide hope in the treatment of patients with chronic demyelinating disorders.

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