• L Elit, L Zitzelsberger, M Fung-Kee-Fung, M Brouwers, I D Graham, G Browman, P Hoskins, S Lau, P Ghatage, and Society of Gynecologic Oncologists of Canada.
• Juravinski Cancer Centre, Hamilton, Ontario, Canada. laurie.elit@hrcc.on.ca <laurie.elit@hrcc.on.ca>
• Gynecol. Oncol. 2007 Jul 1; 106 (1): 181-92.

ObjectiveTo develop a guidance document concerning the use of systemic therapy for women with recurrent ovarian cancer that would be applicable for the Canadian health care system. This will be done using a standardized systematic review process, guideline evaluation instruments, multi-disciplinary expert consensus opinion and evidence-rating systems.Data SelectionThe primary data sources were MEDLINE, National Guideline Clearinghouse and Cochrane Library.MethodsClinical practice guidelines, technology assessments, systematic reviews and randomized controlled trials addressing systemic therapy for women with recurrent ovarian cancer were eligible.Data ExtractionData was identified and extracted by the methodology team and reviewed by the authors. Results were reviewed and discussed by members of an expert working group comprised of a multidisciplinary and geographic divergent group of practitioners.Data SynthesisThe existing 7 practice guidelines underwent formal evaluation for quality, currency and content using the AGREE tool. Recommendations with evidence-ratings were developed. This data was used by a pan-Canadian panel in an informal consensus process, which resulted in the initial draft of a guideline. The guideline team reviewed the draft and made further edits to ensure the guideline's appropriateness for a national context. Practitioner feedback was requested from 165 health care providers who treat ovarian cancer from across Canada. Overall response rate was 37% and was very positive. Comments were reviewed and the guideline was edited appropriately.ConclusionThe development of a national practice guideline on the use of systemic therapy for recurrent ovarian cancer was feasible using systematic literature review, expert consensus, guideline evaluation instruments, evidence-rating systems, independent internal and external review measures and final approval by a national discipline specific society (GOC). Recommendations for practice are offered.

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