• Curr Probl Cancer · May 2017

    Pediatric oncology enters an era of precision medicine.

    • Nita L Seibel, Katherine Janeway, Carl E Allen, Susan N Chi, Yoon-Jae Cho, Julia L Glade Bender, AeRang Kim, Theodore W Laetsch, Meredith S Irwin, Naoko Takebe, James V Tricoli, and Donald Williams Parsons.
    • Division of Cancer Treatment and Diagnosis, Clinical Investigations Branch, National Cancer Institute, Rockville, Maryland. Electronic address: Seibelnl@mail.nih.gov.
    • Curr Probl Cancer. 2017 May 1; 41 (3): 194-200.

    AbstractWith the use of high-throughput molecular profiling technologies, precision medicine trials are ongoing for adults with cancer. Similarly, there is an interest in how these techniques can be applied to tumors in children and adolescents to expand our understanding of the biology of pediatric cancers and evaluate the clinical implications of genomic testing for these patients. This article reviews the early studies in pediatric oncology showing the feasibility of this approach, describe the future plans to evaluate the clinical implications in a multicenter clinical trial and identify the challenges of applying genomics in this patient population.Published by Elsevier Inc.

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