• Stefan Schumann, Michael Lichtwarck-Aschoff, Christoph Haberthür, Claudius A Stahl, Knut Möller, and Josef Guttmann.
• Section for Experimental Anesthesiology, University Hospital of Freiburg, Germany. stefan.schumann@uniklinik-freiburg.de <stefan.schumann@uniklinik-freiburg.de>
• Respir Physiol Neurobiol. 2007 Mar 15; 155 (3): 227-33.

AbstractRapid airway occlusions during mechanical ventilation are followed immediately by high-frequency pressure oscillations. To answer the question if the frequency of forced pressure oscillations is an indicator for partial obstruction of the endotracheal tube (ETT) we performed mathematical simulations and studies in a ventilated physical lung model. Model-derived predictions were evaluated in seven healthy volunteers. Partial ETT obstruction was mimicked by decreasing the inner diameter (ID) of the ETT. In the physical model ETTs of different ID were used. In spontaneously breathing volunteers viscous fluid was applied into the ETT's lumen. According to the predictions derived from mathematical simulations, narrowing of the ETT's ID from 9.0 to 7.0mm decreased the frequency of the pressure oscillations by 11% while changes of the respiratory system's compliance had no effect. In volunteers, a similar reduction (10.9%) was found when 5 ml fluid were applied. We conclude that analysis of pressure oscillations after flow interruption offers a tool for non-invasive detection of partial ETT obstruction.

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