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- T Suzuki, T Mori, M Tsuji, M Misawa, and H Nagase.
- Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
- Life Sci. 1994 Jan 1; 55 (17): PL339-44.
AbstractThe effects of delta-receptor antagonists on cocaine- and methamphetamine-induced place preferences were examined in rats. Cocaine- and methamphetamine-induced place preferences were significantly attenuated by naltrindole (NTI: a non-selective delta-opioid receptor antagonist). Furthermore, naltriben (NTB: a selective delta 2-opioid receptor antagonist), but not 7-benzylidenenaltrexone (BNTX: a selective delta 1-opioid receptor antagonist), attenuated the cocaine- and methamphetamine-induced place preferences. These results suggest that delta-opioid receptors, particularly delta 2-opioid receptors, may be involved in the reinforcing effects of cocaine and methamphetamine.
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