• Gac Med Mex · Jan 2019

    Evaluación semicuantitativa de gliomas cerebrales en adultos: un enfoque de las características neuropatológicas.

    • Marco Antonio Rodríguez-Florido, Iris A Feria-Romero, Bárbara Nettel-Rueda, José Guerrero-Cantera, Sandra Orozco-Suárez, Jesús A Chavez, Gerardo Guinto, and Israel Grijalva.
    • Unidad de Investigación Médica en Enfermedades Neurológicas, Ciudad de México, México.
    • Gac Med Mex. 2019 Jan 1; 155 (5): 473-480.

    IntroductionGliomas are neoplasms with high recurrence and mortality. Due to the difficulty to apply the World Health Organization (2016) classification, developing countries continue to use histological evaluation to diagnose and classify these neoplasms.ObjectiveTo develop a semi-quantitative scale to numerically grade gliomas morphological characteristics.MethodA cohort of patients with gliomas was assessed and followed for 36 months. Tumor tissue sections were analyzed and graded, including aspects such as cell line, cellularity, nuclear pleomorphism, mitosis, endothelial hyperplasia, hypoxic changes, apoptotic bodies, necrosis, hemorrhage and proliferation index.Results58 cases were analyzed. Low-grade gliomas median score was 12 points (9 and 13.5 for percentiles 25 and 75, respectively), whereas for high-grade gliomas it was 17 points (16 and 20.5 for percentiles 25 and 75, respectively) (p < 0.0001). Thirty-six-month survival of patients with low (13/17) and high grade gliomas (6/41) was also significantly different (p < 0.0001).ConclusionsThe semi-quantitative morphological scale allows an objective evaluation of gliomas, with an adequate correlation between the score, tumor grade and survival time.Copyright: © 2019 Permanyer.

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