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- Maura Romeo, Maria de Lourdes Chauffaille, Maria Regina R Silva, Daniella M M Bahia, and José Kerbauy.
- Disciplina de Hematologia e Hemoterapia, Rua Botucatu 740, 3.o Andar, 04023-900, UNIFESP/EPM, SP, São Paulo, Brazil
- Leuk. Res. 2002 Nov 1; 26 (11): 993-6.
AbstractKaryotyping is important for diagnosis and prognosis of myelodysplastic syndrome (MDS). Using fluorescence in situ hybridization (FISH) either mitotic or interphase cells can be analyzed and a higher number of cells can be screened. This study evaluated the effectiveness of FISH in detecting the most common chromosomal abnormalities [-5/del 5q/-7/+8/del 11q23 and -Y] in 40 patients with MDS. Karyotype detected abnormalities in 35.2% of the patients and FISH in 35%, while some abnormalities remained undetected by each approach but the association of both methods increased the detection rate up to 40%.
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