• Diagn. Microbiol. Infect. Dis. · Jun 2015

    Can serum level of HBsAg differentiate HBeAg-negative chronic hepatitis B from inactive carrier state?

    • Shahnaz Sali, Heidar Sharafi, Seyede Hoda Alavian, Seyed Moayed Alavian, Faranak Etesam, Shima Salimi, Muayad A Merza, and Maryam Keshvari.
    • Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran; Iran Hepatitis Network, Tehran, IR Iran.
    • Diagn. Microbiol. Infect. Dis. 2015 Jun 1; 82 (2): 114-9.

    AbstractHepatitis B envelope antigen (HBeAg)-negative hepatitis B virus (HBV) infection exerts both inactive carrier (IC) state and chronic hepatitis B (CHB), which are sometimes difficult to be differentiated. We aimed to assess the role of hepatitis B surface antigen (HBsAg) level in differentiation of CHB and IC among a group of chronic HBeAg-negative HBV-infected patients. A total of 251 HBeAg-negative HBV-infected patients were enrolled. Serum HBV DNA and HBsAg levels were determined for each patient. HBV DNA quantification with cutoff value 2000IU/mL for diagnosis of CHB had 99.0% sensitivity and 74.1% specificity. A cutoff value of HBsAg level at 1000IU/mL was more reliable for diagnosis of CHB with 82.7% sensitivity and 66.2% specificity than other HBsAg cutoff values. There was a positive correlation between HBV DNA and HBsAg levels in both CHB (r=0.42, P<0.001) and IC (r=0.43, P<0.001) groups. Single-point HBsAg quantification did not have enough sensitivity and specificity for differentiation of HBeAg-negative CHB and IC state. Copyright © 2015 Elsevier Inc. All rights reserved.

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