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IEEE Trans Neural Syst Rehabil Eng · Oct 2009
Long micro-channel electrode arrays: a novel type of regenerative peripheral nerve interface.
- Stéphanie P Lacour, James J Fitzgerald, Natalia Lago, Edward Tarte, Stephen McMahon, and James Fawcett.
- Nanoscience Centre, Department of Engineering, University of Cambridge, Cambridge CB30FF, U.K. spl37@cam.ac.uk
- IEEE Trans Neural Syst Rehabil Eng. 2009 Oct 1; 17 (5): 454-60.
AbstractWe have demonstrated that micro-channel electrode arrays with 100 microm x 100 microm cross-section channels support axon regeneration well, and that micro-channels of similar calibre and up to 5 mm long can support axon regeneration and vascularisation. They may be microfabricated using silicon, silicone, or polyimide and thin metal films to form 3-D bundles of long micro-channels. Arrays of "mini-nerves," i.e., miniature nerve fascicles with their own blood vessels, successfully grew through implants 0.5-5 mm long. Furthermore, guiding the regenerating nerve fibres into the small insulating channels allows for a significant increase of the extracellular (recordable) amplitude of action potentials, which promises considerable improvement for in vivo electrophysiology.
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