• Laurie Karamessinis, Patricia Galster, Brian Schultz, Joanne Elliott, Thornton A Mason, Lee J Brooks, Paul R Gallagher, and Carole L Marcus.
• The Sleep Center, The Children's Hospital ofPhiladelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
• Sleep. 2007 Jul 1; 30 (7): 837-43.

Study ObjectivesThe pattern and distribution of rapid eye movement (REM) sleep changes during development, yet there have been few studies of REM density in children. Although children with obstructive apnea syndrome (OSAS) obstruct primarily during REM sleep, the relationship between REM density and obstructive apnea has not been established for this population. We hypothesized that (i) REM density and REM cycle duration increases over the course of the night in children, (ii) the duty cycle (inspiratory time divided by respiratory cycle time) increases over the course of the night in children with suspected OSAS, and (iii) the increase in REM density over the course of the night is associated with increased severity of obstructive apnea.DesignREM density and respiratory parameters were measured during polysomnography.SettingSleep laboratoryPatients76 children with suspected OSAS.InterventionsNA MEASUREMENTS AND RESULTS: REM density and the duration of REM cycles increased over the course of the night until the fifth REM cycle, and then stabilized. The duty cycle increased across the first 6 REM cycles. However, the apnea hypopnea index (AHI) did not increase across REM cycles, and was not affected by the changes in REM density or duty cycle. We speculate that the increase in the duty cycle is a compensatory response to increased upper airway loads during sleep, and that this may lead to ventilatory or upper airway muscle fatigue.

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